Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game

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Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game.

Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins that play an important role in the regulation of blood coagulation as natural anticoagulants. PC is activated by thrombin and the resulting activated PC (APC) inactivates membrane-bound activated factor VIII and factor V. The free form of PS is an important cofactor of APC. Deficiencies in these proteins lead to an increase...

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Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin.

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ژورنال

عنوان ژورنال: Clinical Chemistry and Laboratory Medicine

سال: 2010

ISSN: 1437-4331,1434-6621

DOI: 10.1515/cclm.2010.369